Laciana, Ḷḷaciana in Leonese language (also written Tsaciana), is a comarca in the province of León, Spain. It had 11,904 inhabitants in 2005. The rivers of this comarca flow towards the Atlantic Ocean. Local people speak a certain variant of the Leonese language known as Patsuezo.
Many areas in Laciana were degraded in the past by open-pit mining and mining-related contamination. This comarca was declared a Biosphere Reserve in 2003.